Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvantsArticle Published on 2022-11-302022-11-15 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 진단, [키워드] abrogated ACE2 addition adjuvant adjuvants Adsorption alum aluminum analysis Antigen approach binding booster Combination Complete conformational Coverage COVID-19 COVID-19 vaccine CpG decrease demonstrated destabilized domain dose ELISA exacerbated facilitate Formulation highlight host cell receptor immune responses immunogenicity IMPROVE in vitro in vivo Interaction interactions mice neutralize neutralizing antibody profile Protein RBD RBD antigen SARS-CoV-2 SARS-CoV-2 pseudovirus spike stability stability profile subunit vaccines temperature the receptor-binding domain Vaccine vaccine. while [DOI] 10.1080/21645515.2022.2079346 PMC 바로가기
Reduction of Infusion Time Using a 10% Intravenous Immunoglobulin Formulation With a 15-Minute Rate Escalation Protocol During Staffing Shortages Due to COVID-19Article Published on 2022-11-012022-11-15 Journal: Journal of infusion nursing : the official publica [Category] 진단, [키워드] Analysis changed condition conducted COVID-19 COVID-19 pandemic database decrease dose Escalation evaluated facilitate faster Formulation home infusion Intravenous immunoglobulin IVIG Nurse Patient protocol Rate receiving reduce required retrospective Safe the mean time Treatment Trial [DOI] 10.1097/NAN.0000000000000488 PMC 바로가기
Artificial Cell Membrane Polymersome-Based Intranasal Beta Spike Formulation as a Second Generation Covid-19 VaccineArticle Published on 2022-10-252022-11-15 Journal: ACS Nano [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, [키워드] ACM acute respiratory syndrome adverse effect airway antibodies antibody antigen presenting cells artificial Beta Beta spike C57BL/6 cell membrane clinical symptom clinical trial component conditions coronavirus coronavirus disease COVID-19 CpG cross-neutralizing current delivery of cargo dendritic cells dose doses evaluate evaluated Formulation generate Generation Good hamster hamsters immune responses immunization immunogenic induce Infection initiated interval intranasal mice neutralize neutralizing antibody neutralizing responses New omicron Phase 1 polymersome Practice PROTECT reduction repeated Safety SARS-CoV-2 second serum IgG spike Spike protein Spike-based vaccine Support Toxicity upper respiratory tract Vaccine vaccine. variants viral clearance Viral load virus weight loss wild type [DOI] 10.1021/acsnano.2c06350 PMC 바로가기
Squalene in oil-based adjuvant improves the immunogenicity of SARS-CoV-2 RBD and confirms safety in animal models오일 기반 보조제의 스쿠알렌은 SARS-CoV-2 RBD의 면역원성을 개선하고 동물 모델에서 안전성을 확인합니다Article Published on 2022-08-232022-09-11 Journal: PLoS ONE [Category] SARS, 변종, 진단, 치료기술, [키워드] accelerated adjuvant Analysis animal model assays binding Cellular immune response Chromatography conditions COVID-19 demonstrated determine determined by elicited ELISA etiologic agent evaluated expressed flow cytometry Formulation hamsters histopathological humoral immune immunization immunogenicity IMPROVE insect cell insect cells kidney lead liver Lungs mice Neutralizing antibodies neutralizing antibody pandemic Protein purified RBD of SARS-CoV-2 RBD protein receptor Safe SARS-CoV-2 SARS-CoV-2 RBD sera shown squalene stimulate sub-unit vaccine the Spike Vaccine vaccine candidate variant virus water [DOI] 10.1371/journal.pone.0269823 PMC 바로가기 [Article Type] Article
Platform for Active Vaccine Formulation Using a Two-Mode Enhancement Mechanism of Epitope Presentation by Pickering Emulsion피커링 에멀젼에 의한 에피토프 제시의 2-모드 향상 메커니즘을 사용한 활성 백신 제형을 위한 플랫폼Article Published on 2022-08-152022-09-12 Journal: ACS applied bio materials [Category] SARS, 진단, [키워드] Administered ambient antigenic Antisera applied approach Concentration conditions conjugate correlated determinants Efficacy Efficiency Emulsion enhancement epitope epitope-based vaccination Formulation heterogeneity IgG IgG titer Immunoglobulin include magnitude Pathogens peptide Pickering emulsion plant virus platform presentation subsequent subunit subunit vaccines vaccination Vaccine development Virus-like-particles. vivo assay VLPs [DOI] 10.1021/acsabm.2c00410 PMC 바로가기 [Article Type] Article
A randomized, controlled, blinded, parallel group, clinical trial to study the role of Ayurcov (AyurCoro3), one day regimen as an adjuvant therapy for COVID-19 disease management, at dedicated Covid Hospital (DCH) in India인도의 코비드 전용 병원(DCH)에서 COVID-19 질병 관리를 위한 보조 요법으로서 Ayurcov(AyurCoro3)의 역할을 연구하기 위한 무작위, 통제, 맹검, 병렬 그룹 임상 시험Randomized Controlled Trial Published on 2022-08-012022-09-11 Journal: Complementary therapies in medicine [Category] SARS, 임상, 치료제, [키워드] adjuvant adverse events alternative medicine alum Antiviral Ayurcov Ayurveda blinded CAM carried Chain Reaction clinical trial complementary Complementary and alternative medicine. control group Controlled trial COVID-19 COVID-19 disease COVID-19 infections Ct values Curcuma Day diagnosed discharge disease dose evaluate Formulation functional Functional status higher risk India ingredient Limited management Mild mild to moderate Mild-to-moderate milk moderate outcome parallel group Patient polymerase chain polymerase chain reaction proportion Randomized real time receiving recruited reduction in regimen resolution of symptom reverse transcriptase Reverse transcriptase polymerase chain reaction Rock Candy rRT-PCR severe COVID-19 disease Severe COVID-19 Infection severe symptoms severity significantly significantly lower significantly more Sita Standard of care Symptom symptom resolution therapeutic effect therapeutic options therapy for COVID-19 transcriptase Treatment Urine [DOI] 10.1016/j.ctim.2022.102824 PMC 바로가기 [Article Type] Randomized Controlled Trial
Intranasal immunization with a proteosome-adjuvanted SARS-CoV-2 spike protein-based vaccine is immunogenic and efficacious in mice and hamsters프로테오솜 보조제가 첨가된 SARS-CoV-2 스파이크 단백질 기반 백신을 사용한 비강내 면역은 마우스와 햄스터에서 면역원성과 효능이 있습니다.Article Published on 2022-06-132022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition Antigen B.1.351 B.1.617.2 Beta binding Blood body weight Body weight loss cellular Delta disease evaluated Formulation hamster help IgA titers IgG immune responses immunization immunogenic intranasal Lungs mice mucosal mucosal surface Neutralizing activity offer pandemic persistence prefusion Prevent profile protective immune response Protein protein subunit vaccine reduce reducing reference strain resistin robust SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic SARS-CoV-2 spike SARS-CoV-2 vaccine serum antibodies serum antibody spike Spike protein Subunit vaccine the SARS-CoV-2 Vaccine variants variants of concern Viral viral entry Viral load viral spike protein weight loss [DOI] 10.1038/s41598-022-13819-5 PMC 바로가기 [Article Type] Article
[Vaccines against coronavirus disease 2019 (COVID-19) : Efficacy comparison, safety aspects, and current challenges][2019 코로나바이러스 감염증(COVID-19) 예방백신 : 효능비교, 안전성 측면 및 당면과제]Review Published on 2022-06-012022-09-11 Journal: Innere Medizin (Heidelberg, Germany) [Category] MERS, 변종, 진단, [키워드] activated Adaptability adjuvant adjuvants adverse effects CD4 CD4+ cellular children coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccines COVID-19 vaccines/adverse effects disadvantage Disadvantages English Formulation humoral Humoral immunity Immunity, cellular Immunity, humoral Immunocompromised patients Immunosuppression mRNA vaccines mRNA vaccines. myocarditis Neutralizing antibodies neutralizing antibody pandemic patients physicochemical pregnant women Spectrum Spike protein stability the spike protein thrombotic Thrombotic thrombocytopenia titer vaccination Vaccine vector Viral Viral variants [DOI] 10.1007/s00108-022-01325-9 PMC 바로가기 [Article Type] Review
Ethosome as antigen delivery carrier: optimisation, evaluation and induction of immunological response via nasal route against hepatitis BArticle Published on 2022-06-012023-06-11 Journal: Journal of microencapsulation [Category] B형 간염, [키워드] Antigen ethosome Formulation HBsAg immune system nasal route. [DOI] 10.1080/02652048.2022.2084169 PMC 바로가기
Comparative bioavailability study following a single dose intravenous and buccal administration of remdesivir in rabbits토끼에서 렘데시비르의 단일 용량 정맥내 및 협측 투여 후 비교 생체이용률 연구Article Published on 2022-05-252022-09-11 Journal: International journal of pharmaceutics [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] administration Antiviral Beta-cyclodextrin Bioavailability blood collection Buccal Buccal administration can be used Comparative early stage effective ether FDA-approved drug Formulation GS-441524 hospitalized patient hospitalized patients IMPROVE Infection intravenous Intravenous administration intravenous route intravenously metabolite Pharmacokinetic study pharmacokinetics plasma provided Rabbits Remdesivir remdesivir. required SARS-COV-2 infection significantly lower single dose treated Treatment [DOI] 10.1016/j.ijpharm.2022.121739 PMC 바로가기 [Article Type] Article